Endocrine Abstracts

Background: Dapagliflozin was the first SGLT2 inhibitor licensed in UK to improve glycaemic control in type 2 diabetes. The study aimed to assess impact of dapagliflozin on glucose, weight and BP and identify factors predictive of glycaemic response in a large cohort.Methods: Observational retrospective data collected on all patients prescribed dapagliflozin across primary and secondary care in two Scottish health board areas. HbA1c, weight, BP and conco...

A retrospective single centre audit was conducted on the effects of polycythaemia in trans-male and native male.Polycythaemia is a recognised side effect of testosterone treatment. It could be viewed as a maker of excess testosterone action. We examined whether lipid profiles as a marker of cardiovascular risk differed in a population of polycythaemic transmen (TM) and native males (NM).Forty-six NM and 12 TM were identified to hav...

Introduction: Thyroid Ultrasound (US) is the recommended first line investigation of suspected thyroid nodules. Specific radiological features, such as micro-calcification, low echogenicity, solid consistency, heterogeneity and ill-defined margins, raise the possibility of underlying malignancy. These findings together with fine needle aspiration cytology guide the management of thyroid nodules. The aim of this audit was to evaluate the quality and adequacy of thyroid US repor...

Introduction: Testosterone deficiency is associated with an increased risk of type-2 diabetes (T2D) in men. Physiological testosterone replacement (TRT) improves insulin resistance and glycaemic control in hypogonadal men with T2D. The mechanisms underlying these actions remain unknown, but may be due in part to an effect on the liver as a major metabolic organ involved in glucose regulation. We have previously shown in testicular feminised mice, which have low testosterone le...

Long-term liquorice ingestion is a well-known cause of secondary hypertension and hypokalemia. However, its initial presentation with a very severe hypokalemia and rhabdomyolysis is exceedingly rare. We report a 46-year-old gentleman who presented with acute onset bilateral leg weakness. Medication included allopurinol, aminophylline, fluoxetine, gabapentin, omeprazole, and inhalers. He had a 40 pack year smoking history and drank alcohol heavily in the past.<p class="abst...

Introduction:: The hypothalamus is intimately involved in weight homeostasis. Pituitary tumours and treatment for pituitary tumours has been well described to induce obesity in certain subjects presumably due hypothalamic irritation or dysfunction. This is often very challenging to treat.GLP-1 analogues have direct central effects and have been shown to be effective for weight loss in obese patients with and without diabetes mellitus.<p class="abstex...

C-type natriuretic peptide (CNP) has recently been implicated as a key meiotic arrest factor in oocytes, and mechanistic studies suggest that the transcriptional regulation of the CNP gene (Nppc) and of its receptor, GC-B (Npr2) is sensitive to gonadotrophin-dependent cAMP accumulation. We have shown CNP to be a major regulator of gonadotrophs in the pituitary, but have yet to establish how either Nppc or Npr2 are transcriptionally controlled locally. In the current study, the...

Background: Gonadotroph adenomas are the most common non-functioning pituitary adenomas in adult1, 2. However, functioning gonadotrophinomas are rare. Here, we describe an unusual presentation of concurrent acromegaly and functioning FSHoma (FSH-secreting pituitary adenoma).A 39-year-old man presented with a vague visual disturbance to the optometrist and a bitemporal hemianopia was detected.Further questioning elicited ...

Background: In Scotland median age at notification with elevated capillary (c) TSH (>25 initially or >8 μ/l on repeat testing) is 10 (range 3–35) days. If cTSH elevation is >100 μ/l decompensated hypothyroidism (moderate: free (f) T4 5 −<10, severe: <5 pmol/l) is likely and thyroxine treatment should start without delay. If TSH elevation is mild the clinician may prefer to wait for venous (v) fT4 result and observe the infant’s pro...

Fatty liver (Hepatic Steatosis) is common in men with type 2 diabetes mellitus (T2DM). Furthermore there is a high prevalence of testosterone deficiency (up to 40%) in this population. Testosterone replacement therapy (TRT) has been shown to reduce elevated serum liver transaminase levels in hypogonadal men. The testicular feminised (Tfm) mouse exhibits a non-functional androgen receptor (AR) and low circulating testosterone levels. We have previously shown that a high-fat die...